Although not officially confirmed, the apparent destruction of a Ukrainian Challenger 2 is the first ever loss during combat operations.
Russian army destroyed first UK Challenger 2 tank in Ukraine
UK Rejects Claim That Giving Ukraine Tanks Reduces Operational Capability
Second British-made Challenger 2 tank destroyed in Ukraine – RIA — RT Russia & Former Soviet Union
News & Features - Defence Leaders 2023
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UK-manufactured Challenger 2 Tank reported destroyed in Ukraine conflict - AOAV
Why did British bosses ban Ukraine from using Brit Challenger tanks in the battlefield? Was it to prevent the brand destruction suffered by pictures of burning Leopards and Bradleys? - Quora
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Ukraine Has Lost Its First Challenger 2 Tank
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News & Features - Defence Leaders 2023
British Challenger 2 tank destroyed in combat for first time, Ukraine footage shows, Ukraine