Surgical stress and cancer progression: the twisted tango

Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.

Full article: Surgical Trauma-induced CCL2 Upregulation Mediates

Full article: Surgical Trauma-induced CCL2 Upregulation Mediates

PDF) Surgical stress and cancer progression: the twisted tango

Surgical treatment and overall survival in patients with right

Surgical stress and cancer progression: the twisted tango

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